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PD0332991 (Palbociclib) for treatment of pediatric intracranial growing teratoma syndrome
Author(s) -
Schultz Kris Ann P.,
Petronio Joseph,
Bendel Anne,
Patterson Richard,
Vaughn David J.
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25338
Subject(s) - medicine , palbociclib , teratoma , germ cell tumors , mature teratoma , chemotherapy , cancer , surgery , metastatic breast cancer , breast cancer
Growing teratoma syndrome is characterized by growth of mature teratoma elements of a mixed germ cell tumor despite resolution of immature/malignant elements with administration of chemotherapy. Surgical resection is the only known cure for growing teratoma syndrome but in the brain, complete resection may be impossible. In these instances, mature teratoma, although histologically benign, may be fatal. In this report, we present the case of a child with a large, rapidly growing, unresectable pineal region growing teratoma. PD0332991 was administered with stabilization of the solid, enhancing components of the mass. Minimal adverse effects were noted. Pediatr Blood Cancer 2015;62:1072–1074. © 2014 Wiley Periodicals, Inc.