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KIAA1549:BRAF fusion gene in pediatric brain tumors of various histogenesis
Author(s) -
Antonelli Manila,
Badiali Manuela,
Moi Loredana,
Buttarelli Francesca R.,
Baldi Caterina,
Massimino Maura,
Sanson Marc,
Giangaspero Felice
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25272
Subject(s) - histogenesis , pilocytic astrocytoma , medicine , pathology , fusion gene , ependymoma , anaplasia , atypical teratoid rhabdoid tumor , anaplastic astrocytoma , grading (engineering) , astrocytoma , pleomorphic xanthoastrocytoma , anaplastic lymphoma kinase , glioma , immunohistochemistry , cancer research , gene , biology , lung cancer , ecology , biochemistry , malignant pleural effusion
The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma. We investigated a series of 69 pediatric brain neoplasms of diverse histogenesis and grade using the RT‐PCR and sequencing. We detected the KIAA1549:BRAF fusion gene in five of 34 non‐PA tumors (14.7%), that is, one glioblastoma, one anaplastic astrocytoma, one anaplastic pleomorphic xanthoastrocytoma, 1 ependymoma, and 1 Atypical Teratoid Rhabdoid Tumor. Our study showed that the K–B, although uncommon, it can be detected in non‐PA tumors of various histogenesis and grading. Pediatr Blood Cancer 2015;62:724–727. © 2014 Wiley Periodicals, Inc.