KIAA1549:BRAF  fusion gene in pediatric brain tumors of various histogenesis | Zendy

Antonelli Manila | Zendy; Badiali Manuela | Zendy; Moi Loredana | Zendy; Buttarelli Francesca R. | Zendy; Baldi Caterina | Zendy; Massimino Maura | Zendy; Sanson Marc | Zendy; Giangaspero Felice | Zendy

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KIAA1549:BRAF fusion gene in pediatric brain tumors of various histogenesis

Author(s) -

Antonelli Manila,

Badiali Manuela,

Moi Loredana,

Buttarelli Francesca R.,

Baldi Caterina,

Massimino Maura,

Sanson Marc,

Giangaspero Felice

Publication year - 2015

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.25272

Subject(s) - histogenesis , pilocytic astrocytoma , medicine , pathology , fusion gene , ependymoma , anaplasia , atypical teratoid rhabdoid tumor , anaplastic astrocytoma , grading (engineering) , astrocytoma , pleomorphic xanthoastrocytoma , anaplastic lymphoma kinase , glioma , immunohistochemistry , cancer research , gene , biology , lung cancer , ecology , biochemistry , malignant pleural effusion

The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma. We investigated a series of 69 pediatric brain neoplasms of diverse histogenesis and grade using the RT‐PCR and sequencing. We detected the KIAA1549:BRAF fusion gene in five of 34 non‐PA tumors (14.7%), that is, one glioblastoma, one anaplastic astrocytoma, one anaplastic pleomorphic xanthoastrocytoma, 1 ependymoma, and 1 Atypical Teratoid Rhabdoid Tumor. Our study showed that the K–B, although uncommon, it can be detected in non‐PA tumors of various histogenesis and grading. Pediatr Blood Cancer 2015;62:724–727. © 2014 Wiley Periodicals, Inc.

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