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Leptomeningeal failure of retinoblastoma
Author(s) -
Orman Amber,
Markoe Arnold,
Johnstone Peter A.S.
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25244
Subject(s) - retinoblastoma , medicine , blood cancer , stage (stratigraphy) , radiation therapy , external beam radiotherapy , surgery , cancer , brachytherapy , paleontology , biochemistry , chemistry , biology , gene
Leptomeningeal (LM) failure of retinoblastoma (Rb) has not previously been reported. Upon review of our institutional experience of external beam radiotherapy (EBRT) for Rb, we found three LM failures. We sought to better define the clinical parameters of this type of recurrence. All children with LM failure had Reese‐Ellsworth stage Vb eyes. Otherwise, no variables were significantly associated with LM failure. We theorize that this phenomenon is a function of the late‐stage eyes for which EBRT is being reserved in the modern era. Pediatr Blood Cancer 2015;62:533–535. © 2014 Wiley Periodicals, Inc.