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Diffuse intrinsic pontine glioma biopsy: A single institution experience
Author(s) -
Wang Zhihong J.,
Rao Latha,
Bhambhani Kanta,
Miller Kathy,
Poulik Janet,
Altinok Deniz,
Sood Sandeep
Publication year - 2015
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25224
Subject(s) - medicine , biopsy , glioma , retrospective cohort study , surgery , stereotactic biopsy , radiology , cancer research
Tumor biopsy is rarely performed in diffuse intrinsic pontine glioma (DIPG) due to the presumed risk of surgical complications, although data on the surgery related morbidity of DIPG biopsy is sparse. We performed a retrospective review on 22 consecutive cases of DIPG diagnosed from 2002 to 2012 at Children's Hospital of Michigan, 15 of which underwent biopsy. Transient new or worsening neurological deficits were observed in three of 15 cases following surgery. No surgery related mortality or permanent deficit was observed, and the mean overall survival was 10.4 ± 3.8 months. Undergoing biopsy did not adversely affect the outcome. Pediatr Blood Cancer 2015;62:163–165. © 2014 Wiley Periodicals, Inc.