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Pan myeloid antigen‐negative pediatric acute megakaryoblastic leukemia
Author(s) -
Cetin Neslihan,
Lorsbach Robert B.
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25103
Subject(s) - acute megakaryoblastic leukemia , medicine , myeloid leukemia , myeloid sarcoma , myeloid , cytogenetics , leukemia , antigen , flow cytometry , down syndrome , cancer research , pathology , immunology , biology , gene , chromosome , psychiatry , biochemistry
Acute megakaryoblastic leukemia (AMKL) is a relatively common type of acute myeloid leukemia in children. We describe two unusual cases of AMKL that by flow cytometry (FC) lacked expression of any commonly evaluated myeloid antigens. One case presented as a periorbital myeloid sarcoma and clinically was thought to be a solid tumor. In both cases, the leukemic blasts were variably positive for the megakaryocytic marker CD61. Cytogenetics confirmed the presence of the t(1;22) in one case. Cytogenetics and inclusion of megakaryocytic markers in FC panels when evaluating pediatric specimens is critical for appropriate diagnosis for myeloid antigen negative AMKL. Pediatr Blood Cancer 2014;61:2089–2091. © 2014 Wiley Periodicals, Inc.