Age‐related differences in urinary 11‐dehydroxythromboxane B2 between infants, children, and adolescents: Another example of developmental hemostasis? | Zendy

Varnell Charles D. | Zendy; Goldstein Stuart L. | Zendy; Yee Donald L. | Zendy; Teruya Jun | Zendy; Guyer Kirk E. | Zendy; Siddiqui Shakeel | Zendy; Jefferies John L. | Zendy

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Age‐related differences in urinary 11‐dehydroxythromboxane B2 between infants, children, and adolescents: Another example of developmental hemostasis?

Author(s) -

Varnell Charles D.,

Goldstein Stuart L.,

Yee Donald L.,

Teruya Jun,

Guyer Kirk E.,

Siddiqui Shakeel,

Jefferies John L.

Publication year - 2014

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.25089

Subject(s) - urinary system , medicine , urine , hemostasis , aspirin , creatinine , surgery

Our study was developed to ascertain reference ranges of 11‐dehydrothromboxane B2 (11‐dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11‐dehydrothromboxane B 2 . 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11‐dehydrothromboxane B2 ( P = 0.0001). This study confirms a negative correlation between age and level of urinary 11‐dehydrothromboxane B2 and provides a set of age‐specific reference ranges. Pediatr Blood Cancer 2014;61:2074–2076. © 2014 Wiley Periodicals, Inc.

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