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Age‐related differences in urinary 11‐dehydroxythromboxane B2 between infants, children, and adolescents: Another example of developmental hemostasis?
Author(s) -
Varnell Charles D.,
Goldstein Stuart L.,
Yee Donald L.,
Teruya Jun,
Guyer Kirk E.,
Siddiqui Shakeel,
Jefferies John L.
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25089
Subject(s) - urinary system , medicine , urine , hemostasis , aspirin , creatinine , surgery
Our study was developed to ascertain reference ranges of 11‐dehydrothromboxane B2 (11‐dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11‐dehydrothromboxane B 2 . 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11‐dehydrothromboxane B2 ( P = 0.0001). This study confirms a negative correlation between age and level of urinary 11‐dehydrothromboxane B2 and provides a set of age‐specific reference ranges. Pediatr Blood Cancer 2014;61:2074–2076. © 2014 Wiley Periodicals, Inc.