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Malignant transformation of infantile hemangioma to angiosarcoma: Response to chemotherapy with bevacizumab
Author(s) -
Jeng Michael R.,
Fuh Beng,
Blatt Julie,
Gupta Anita,
Merrow Arnold C.,
Hammill Adrienne,
Adams Denise
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.25067
Subject(s) - medicine , bevacizumab , angiosarcoma , chemotherapy , vascular endothelial growth factor , malignant transformation , hemangioma , infantile hemangioma , pathology , oncology , vegf receptors
We describe a child initially diagnosed with multi‐focal infantile hemangioma (cutaneous, hepatic, pulmonary), a benign vascular lesion, which underwent malignant transformation to angiosarcoma. The use of anti‐angiogenic agents, such as bevacizumab, an anti‐vascular endothelial growth factor (VEGF) antibody, has been reported in adults with angiosarcoma. Treatment with chemotherapy (gemcitabine and docetaxel) and bevacizumab resulted in disease response with progression free survival of 12 months. This report describes the response to chemotherapy and bevacizumab in a child with angiosarcoma and highlights the potential for malignant transformation of benign vascular lesions and the need for careful monitoring. Pediatr Blood Cancer 2014;61:2115–2117. © 2014 Wiley Periodicals, Inc.