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Tuberculosis in pediatric oncology and bone marrow transplantation patients
Author(s) -
Cruz Andrea T.,
Airewele Gladstone,
Starke Jeffrey R.
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24985
Subject(s) - medicine , tuberculosis , hepatoblastoma , pediatrics , latent tuberculosis , blood cancer , bone marrow , disease , chemotherapy , surgery , cancer , mycobacterium tuberculosis , pathology
Five children with malignancies (3 hematologic, 1 medulloblastoma, 1 hepatoblastoma) and one bone marrow transplant patient were treated for tuberculosis over a 30‐year period. Three had pulmonary disease, 3 disseminated tuberculosis, and 1 had scrofula. Four of five had positive tuberculin skin tests, cultures were positive in 5/6 children. One child died of disseminated TB after engraftment, and one child had hepatotoxicity likely related to tuberculosis therapy. All cases were potentially preventable had they been screened due to established risk factors of foreign birth (4/6) or parental foreign birth (2/6). All children should be screened for latent tuberculosis before chemotherapy. Pediatr Blood Cancer 2014; 61:1484–1485. © 2014 Wiley Periodicals, Inc.