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Immune‐mediated mechanism for thrombocytopenia after Loxosceles spider bite
Author(s) -
Levin Carina,
Bonstein Lilach,
Lauterbach Roy,
Mader Rivka,
Rozemman Dganit,
Koren Ariel
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24959
Subject(s) - spider , medicine , malaise , vomiting , immune system , antibody , lesion , platelet , immunology , blood cancer , dermatology , cancer , pathology , biology , zoology
Loxoscelism, characterized by high fever, vomiting, malaise, a dermonecrotic lesion, and thrombocytopenia, was diagnosed in a 3‐year‐old female. Clinical laboratory and dermatological signs are described. Blood test showed a transient hypercoagulable state and the presence of IgG antibodies against platelets, suggesting an immune‐mediated mechanism for platelet destruction, in addition to the direct toxic effect of the spider venom. The finding of platelet antibodies after a Loxosceles spider bite has not been previously reported. Pediatr Blood Cancer 2014; 61:1466–1468. © 2014 Wiley Periodicals, Inc.