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Ependymoblastoma of the brainstem: MRI findings and differential diagnosis
Author(s) -
Nowak Johannes,
Seidel Carolin,
Pietsch Torsten,
Friedrich Carsten,
von Hoff Katja,
Rutkowski Stefan,
WarmuthMetz Monika
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24915
Subject(s) - brainstem , pathology , differential diagnosis , central nervous system , lumen (anatomy) , medicine , blood cancer , cancer , biology
Ependymoblastoma (EBL) is a rare malignant CNS tumor of early childhood, listed as a subgroup of primitive neuroectodermal tumors (PNET) in the 2007 WHO Classification of Tumours of the Central Nervous System. Histologically, EBL can be defined by multilayered, mitotically active “ependymoblastic” rosettes with central lumen as a histological hallmark. The prognosis seems to be far inferior to other embryonal CNS tumors, and known clinical and MRI characteristics of EBL are based on scattered case reports. We present and discuss two uncommon cases of histopathologically confirmed ependymoblastoma that both seem to originate from the brainstem. Pediatr Blood Cancer 2014;61:1132–1134. © 2014 Wiley Periodicals, Inc.