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Reduced intensity conditioning in allogeneic stem cell transplantation for AML with Down syndrome
Author(s) -
Muramatsu Hideki,
Sakaguchi Hirotoshi,
Taga Takashi,
Tabuchi Ken,
Adachi Souichi,
Inoue Masami,
Kitoh Toshiyuki,
Suminoe Aiko,
Yabe Hiromasa,
Azuma Eichi,
Shioda Yoko,
Ogawa Atsushi,
Kinoshita Akitoshi,
Kigasawa Hisato,
Osugi Yuko,
Koike Kazutoshi,
Kawa Keisei,
Kato Koji,
Atsuta Yoshiko,
Kudo Kazuko
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24883
Subject(s) - medicine , transplantation , stem cell , conditioning , oncology , hematopoietic stem cell transplantation , genetics , statistics , mathematics , biology
Allogeneic hematopoietic stem cell transplantation (HSCT) has not been widely used in patients with acute myeloid leukemia (AML) and Down syndrome (DS) due to fear of transplantation‐related toxicity. A retrospective analysis of the outcome of allogeneic HSCT was conducted in 15 patients with AML and DS. The five patients transplanted with the reduced intensity conditioning (4 in complete remission (CR) and 1 in non‐CR) had a significantly better survival rate than 10 patients transplanted with a conventional conditioning (4 in CR and 6 in non‐CR) (3‐year EFS (95% confidence interval): 80.0% (20.4–96.9%) vs. 10.0% (0.6%–35.8%), P = 0.039). Pediatr Blood Cancer 2014;61:925–927. © 2013 Wiley Periodicals, Inc.