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Treatment of a tongue lymphangioma with sirolimus after failure of surgical resection and propranolol
Author(s) -
Akyüz Canan,
Ataş Erman,
Varan Ali
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24866
Subject(s) - medicine , sirolimus , lymphangioma , tongue , surgery , propranolol , anesthesia , pathology
Lymphangiomas of the tongue are rare, and their treatment is problematic. A 10 year‐old patient with tongue lymphangioma who was previously treated with surgery and propranolol with no response was treated with sirolimus in our department. We used sirolimus with a dose of 1.6 mg/m 2 /day. After 3 months of treatment, the mass had decreased by more than 60%. We continued the treatment for 1 year with a maximum response of 70% decrease in mass. Disease remained stable 6 months after stopping therapy, the latest time of follow‐up. Sirolimus appears to be effective in lymphangioma but requires further study. Pediatr Blood Cancer 2014;61:931–932. © 2013 Wiley Periodicals, Inc.