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Chronic lymphocytic leukemia in a child: A challenging diagnosis in pediatric oncology practice
Author(s) -
Demir Hacı Ahmet,
Bayhan Turan,
Üner Ayşegül,
Kurtulan Olcay,
Karakuş Esra,
Emir Suna,
Özyörük Derya,
Ceylaner Serdar
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24865
Subject(s) - medicine , chronic lymphocytic leukemia , fludarabine , rituximab , cyclophosphamide , blood cancer , oncology , lymphoma , chemotherapy , leukemia , biopsy , cancer , pathology , cancer research
Chronic lymphocytic leukemia/lymphoma (CLL) is an extremely rare disease during childhood. We report a 16‐year‐old female who presented with lymphadenopathies and she was diagnosed as T cell lymphoblastic lymphoma. Her chemotherapy response was minimal and clinical findings were unusual. Therefore, her biopsy specimen was re‐examined and diagnosis was changed to CLL. Chemotherapy protocol including fludarabine, cyclophosphamide, rituximab was administrated and good response was observed. In our patient deletion at 1q21.2 region that includes aryl hydrocarbon receptor nuclear translocator (ARNT) gene was detected via comparative genomic hybridization method. ARNT gene deletion may be a new mutation in chronic lymphocytic leukemia development. Pediatr Blood Cancer 2014;61:933–935. © 2013 Wiley Periodicals, Inc.