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FVIII/VWF ratio is not a reliable predictor of VWD in children
Author(s) -
Branchford Brian R.,
Ruegg Katherine,
VillalobosMenuey Elizabeth,
Jacobson Linda J.,
Di Paola Jorge A.,
MancoJohnson Marilyn
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24860
Subject(s) - medicine , von willebrand disease , von willebrand factor , population , immunology , gastroenterology , platelet , environmental health
Adults with von Willebrand Disease (VWD) are known to have a ratio of factor VIII activity (FVIII:C) to von Willebrand factor antigen (VWF:Ag) greater than 1. We, however, noted healthy children with ratios that are unexpectedly high. Though the FVIII:C/VWF:Ag ratio differs significantly between healthy children and VWD patients in some age groups, the substantial overlap of observed ranges suggests that a ratio threshold‐based screening approach alone cannot reliably discriminate between these groups. The diagnostic performance of this ratio is poor for VWD in children, which may decrease its value as a screening tool in the pediatric population. Pediatr Blood Cancer 2014;61:936–939. © 2013 Wiley Periodicals, Inc.