Premium
Screening for vitamin D insufficiency in pediatric cancer survivors
Author(s) -
Esbenshade Adam J.,
Sopfe Jenna,
Zhao Zhiguo,
Li Zeda,
Campbell Kristin,
Simmons Jill H.,
Friedman Debra L.
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24844
Subject(s) - medicine , blood cancer , pediatric cancer , cancer , vitamin d and neurology , pediatrics , intensive care medicine , insufficiency fracture , osteoporosis
Abstract Background Corticosteroids increase risk for decreased bone mineral density, which can be worsened by vitamin D insufficiency (VDI) or deficiency (VDD). Procedure In the Vanderbilt cancer survivorship clinic, we obtained screening total 25‐hydroxy vitamin D levels (VDL) in 171 cancer survivors <23 years old who were treated with prolonged corticosteroids for their cancer, and compared this group to a control group of 97 healthy pediatric patients. Results VDD was diagnosed in 15.8% and VDI in 34.5% of cancer survivors and VDD/VDI combined was associated with body mass index (BMI) >85th percentile (Odds ratio [OR] = 5.4; P < 0.001), older age (OR = 2.2; P = 0.012), non‐Caucasian or Hispanic race (OR = 4.5; P = 0.008) and summer versus winter season (OR = 0.12; P < 0.001). In multivariable analysis, VDI/VDD prevalence did not differ from the control group (VDI/VDD (43.3%)). In the combined survivor/control group multivariable analysis, cancer diagnosis did not increase VDI/VDD risk, but significant associations persisted with elevated BMI ( P < 0.001), age ( P = 0.004), non‐Caucasian or Hispanic race ( P < 0.001), and seasonality ( P < 0.001). Conclusion VDD/VDI is equally common in pediatric cancer survivors treated with corticosteroids and healthy children. The impact of VDD/VDI in cancer survivors may be greater due to risk for impaired bone health superimposed on that conferred from corticosteroid exposure. Thus, screening VDLs should be obtained in pediatric cancer survivors treated with corticosteroids, particularly in those with elevated BMI, older age, or non‐Caucasian race. Prospective studies evaluating the impact of interventions to minimize VDD/VDI on long‐term bone health in survivors are required. Pediatr Blood Cancer 2014;61:723–728. © 2013 Wiley Periodicals, Inc.