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Health‐related quality of life in children and young adults with post‐thrombotic syndrome: Results from a cross‐sectional study
Author(s) -
Kumar Riten,
Rodriguez Vilmarie,
Matsumoto Jane M.S.,
Khan Shakila P.,
Weaver Amy L.,
McBane Robert D.,
Beebe Timothy J.,
Heit John A.
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24840
Subject(s) - medicine , quality of life (healthcare) , post thrombotic syndrome , cohort , deep vein , thrombosis , health related quality of life , cross sectional study , pediatrics , physical therapy , disease , pathology , nursing
Objective While post‐thrombotic syndrome (PTS) is increasingly recognized in children with a history of deep vein thrombosis (DVT), its impact on the health‐related quality of life (HRQoL) is unknown. Our objective was to evaluate the association between the PTS and HRQoL by surveying a cohort of patients treated at our institution for DVT. Materials/Methods All unique pediatric patients (0–18 years) treated for a DVT at the Mayo Clinic during the 15‐year period, 1995–2009 were identified. A previously validated PTS survey instrument and age appropriate Pediatric Quality of Life inventory, version 4 (PedsQL 4.0) were mailed to eligible patients. Linear regression models were fit to compare the HRQoL scores between PTS groups (none, mild, moderate/severe), after adjusting for the presence of potential covariates. Results Of the 90 respondents, 65 (72%) reported signs and/or symptoms of PTS. Mean age (±SD) at DVT diagnosis and survey completion were 12.8 (±6.1) and 19.3 (±7.7) years, respectively. Self‐report PedsQL 4.0 module was completed by 79 patients, and 34 guardians completed the parent‐proxy module. Patients with moderate to severe PTS reported significantly worse total HRQoL score (mean ± SD, 71.3 ± 13.4) as compared to patients with mild PTS (84.8 ± 14.2) and no PTS (83.4 ± 14) ( P = 0.001). Conclusion Moderate to severe PTS has a significant impact on self‐reported HRQoL as measured using the generic PedsQL 4.0. Further research is warranted to develop a venous disease‐specific quality of life measure for children with a history of DVT. Pediatr Blood Cancer 2014;61:546–551. © 2013 Wiley Periodicals, Inc.