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Comparison of latino and non‐Latino patients with Ewing sarcoma
Author(s) -
Sharib Jeremy,
Horvai Andrew,
Gray Hazard Florette K.,
DaldrupLink Heike,
Goldsby Robert,
Marieyssa,
DuBois Steven G.
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24745
Subject(s) - medicine , sarcoma , malignancy , etiology , socioeconomic status , retrospective cohort study , overall survival , wilcoxon signed rank test , medical record , pediatrics , population , pathology , mann–whitney u test , environmental health
Background Ewing sarcoma (ES) is a malignancy of bone and soft tissue in children and adults. Previous registry‐based studies indicate that Latino patients with ES have inferior outcomes compared to non‐Latino patients, though an etiology for this difference could not be identified. To explore possible differences that might underlie this disparity, we conducted a retrospective study to compare clinical characteristics, tumor features, healthcare access, and treatment outcomes between Latino and non‐Latino patients with ES. Methods Primary data for 218 ES patients treated at two academic medical centers between 1980 and 2010 were collected. Categorical data were compared using Fisher exact tests; Wilcoxon rank‐sum tests were used for continuous variables. Survival was estimated using Kaplan–Meier analysis and compared using log‐rank testing. Results Latino patients were diagnosed at a younger age ( P = 0.014). All other clinical and histological data were similar between groups, including radiologic and histologic response to neoadjuvant chemotherapy. Latino patients had lower socioeconomic status ( P = 0.001), were less likely to have insurance ( P = 0.001), and were more likely to present to the emergency room at onset of symptoms ( P = 0.031) rather than to primary care physicians. Five‐year event free survival (EFS) and overall survival (OS) were similar between Latino and non‐Latino patients (EFS: 60.5% vs. 50.9% P = 0.37; OS: 77.6% vs. 68.6% P = 0.54). Conclusion Latino patients with ES present at a younger age, and have evidence of impaired access to healthcare. Response to initial therapy appears similar between Latino and non‐Latino patients. Pediatr Blood Cancer 2014;61:233–237. © 2013 Wiley Periodicals, Inc.