Premium
Hypersensitivity reaction to high‐dose methotrexate and successful rechallenge in a pediatric patient with osteosarcoma
Author(s) -
Scott Jeffrey R.,
Ward Deborah A.,
Crews Kristine R.,
Panetta John C.,
Navid Fariba
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24741
Subject(s) - methotrexate , medicine , hypersensitivity reaction , regimen , blood cancer , osteosarcoma , chemotherapy , cancer , pharmacology , cancer research
Hypersensitivity reactions to methotrexate are rare, but have been reported. Methotrexate has shown activity against many malignancies, and omission of methotrexate therapy may increase the risk of cancer‐related death in some patients. Therefore, rechallenging patients with methotrexate following hypersensitivity may be beneficial. We report a case of a child with metastatic osteosarcoma who experienced a hypersensitivity reaction to high‐dose methotrexate and was successfully rechallenged with methotrexate using a 6‐hour infusion. Using this regimen, adequate peak methotrexate plasma concentrations were achieved and no further hypersensitivity reactions were noted. Pediatr Blood Cancer 2014;61:373–375. © 2013 Wiley Periodicals, Inc.