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Metabolic syndrome in pediatric cancer survivors: A mechanistic review
Author(s) -
Rosen Galit P.,
Nguyen HoaiTrinh,
Shaibi Gabriel Q.
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24703
Subject(s) - medicine , dyslipidemia , disease , cancer , pediatric cancer , intensive care medicine , diabetes mellitus , blood cancer , metabolic syndrome , bioinformatics , translational research , obesity , pathology , endocrinology , biology
Pediatric cancer survivors have increased risk of obesity, hypertension, dyslipidemia, and type 2 diabetes, leading to premature cardiovascular disease (CVD). Multiple tissues that are involved in glucose homeostasis and lipid metabolism are adversely affected by chemotherapy. This review highlights the relevant tissue and molecular end‐organ effects of therapy exposures and synthesizes the current understanding of the mechanisms underlying CVD risk in this vulnerable population. The review also approaches the topic from a developmental perspective, with the goal of providing a translational approach to identifying the antecedents of overt CVD among survivors of pediatric cancer. Pediatr Blood Cancer 2013;60:1922–1928. © 2013 Wiley Periodicals, Inc.