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Interchangeability between 24‐hour collection and single spot urines for vanillylmandelic and homovanillic acid levels in the diagnosis of neuroblastoma
Author(s) -
Cangemi Giuliana,
Barco Sebastiano,
Reggiardo Giorgio,
Viscardi Elisabetta,
Di Cataldo Andrea,
Garaventa Alberto,
Melioli Giovanni,
Conte Massimo
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24671
Subject(s) - vanillylmandelic acid , homovanillic acid , medicine , neuroblastoma , creatinine , interchangeability , chromatography , chemistry , computer science , serotonin , biology , receptor , genetics , programming language , cell culture
The determination of the two urinary catecholamine metabolites homovanillic acid (HVA) and vanillylmandelic acid (VMA) is of crucial importance for the diagnosis and follow‐up of neuroblastoma (NB). The standard practice for their measurement requires the use of 24‐hour collections that are time consuming and difficult to obtain. In this article, we directly demonstrate that 24‐hour collections and single spot urines are interchangeable for the determination of HVA and VMA expressed as ratio on creatinine concentration. This study can be useful for a faster management of NB at onset. Pediatr Blood Cancer 2013;60:E170–E172. © 2013 Wiley Periodicals, Inc.