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Myelodysplastic syndrome (MDS)‐associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia
Author(s) -
Kumar Kirthi R.,
Koduru Prasad,
Timmons Charles,
Monaghan Sara,
Cavalier MaryEllen,
Luu Hung S.
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24645
Subject(s) - medicine , myelodysplastic syndromes , chronic myelogenous leukemia , chromosome instability , blood cancer , leukemia , cytogenetics , down syndrome , cancer , oncology , cancer research , immunology , genetics , bone marrow , biology , gene , chromosome , psychiatry
Chronic myelogenous leukemia (CML) is very rare in the pediatric population. We report the case of a 2‐year‐old female with CML and concurrent myelodysplastic syndrome (MDS) associated cytogenetic abnormalities. The co‐existence of t(9;22) and chromosomal deletions that are associated with MDS poses a unique diagnostic challenge. Given the reported association of t(9;22) and genomic instability, we hypothesize that the chromosomal deletions represent clonal evolution of the CML. Pediatr Blood Cancer 2013;60:E146–E148. © 2013 Wiley Periodicals, Inc.