Myelodysplastic syndrome (MDS)‐associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia | Zendy

Kumar Kirthi R. | Zendy; Koduru Prasad | Zendy; Timmons Charles | Zendy; Monaghan Sara | Zendy; Cavalier MaryEllen | Zendy; Luu Hung S. | Zendy

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Myelodysplastic syndrome (MDS)‐associated cytogenetic abnormalities in pediatric chronic myelogenous leukemia

Author(s) -

Kumar Kirthi R.,

Koduru Prasad,

Timmons Charles,

Monaghan Sara,

Cavalier MaryEllen,

Luu Hung S.

Publication year - 2013

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.24645

Subject(s) - medicine , myelodysplastic syndromes , chronic myelogenous leukemia , chromosome instability , blood cancer , leukemia , cytogenetics , down syndrome , cancer , oncology , cancer research , immunology , genetics , bone marrow , biology , gene , chromosome , psychiatry

Chronic myelogenous leukemia (CML) is very rare in the pediatric population. We report the case of a 2‐year‐old female with CML and concurrent myelodysplastic syndrome (MDS) associated cytogenetic abnormalities. The co‐existence of t(9;22) and chromosomal deletions that are associated with MDS poses a unique diagnostic challenge. Given the reported association of t(9;22) and genomic instability, we hypothesize that the chromosomal deletions represent clonal evolution of the CML. Pediatr Blood Cancer 2013;60:E146–E148. © 2013 Wiley Periodicals, Inc.

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