Premium
Jumping translocation in a case of De novo infant acute myeloid leukemia
Author(s) -
Parihar Mayur,
Gupta Anurag,
Yadav Anil Kumar,
Mishra Deepak Kumar,
Bhattacharyya Arpita,
Chandy Mammen
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24636
Subject(s) - hepatosplenomegaly , medicine , chromosomal translocation , karyotype , abnormality , myeloid leukemia , chromosome abnormality , bone marrow , leukemia , chromosomal abnormality , pathology , chromosome , genetics , gene , biology , disease , psychiatry
An infant presented with fever and purulent discharge from the left ear, proptosis of the right eye, and hepatosplenomegaly. She was diagnosed with acute monoblastic leukemia on morphological and flowcytometric analysis of the bone marrow. Karyotyping showed a jumping translocation (JT) involving the long arm of chromosome 1 as the sole cytogenetic abnormality in 29 metaphases. The patient died within 2 months of diagnosis. The presence of JT in a de novo infant AML as a sole cytogenetic abnormality indicates its possible role in leukemogenesis unlike previous reports that have implicated its role in tumor progression only. Pediatr Blood Cancer 2014;61:387–389. © 2013 Wiley Periodicals, Inc.