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Usefulness of allogeneic hematopoietic stem cell transplantation in first complete remission for pediatric blastic plasmacytoid dendritic cell neoplasm with skin involvement: A case report and review of literature
Author(s) -
Sakashita Kazuo,
Saito Shoji,
Yanagisawa Ryu,
Tanaka Miyuki,
Yoshikawa Kentaro,
Hirabayashi Koichi,
Tsukahara Keiko,
Motobayashi Mitsuo,
Nakazawa Yozo,
Koike Kenichi
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24622
Subject(s) - medicine , complete remission , hematopoietic stem cell transplantation , transplantation , stem cell , blood cancer , haematopoiesis , bone marrow , leukemia , conditioning regimen , oncology , disease , cancer , chemotherapy , biology , genetics
No standard treatment has been established in childhood blastic plasmacytoid dendritic cell neoplasma (BPDCN) because of its rarity. We treated with acute lymphoblastic leukemia‐type regimen for a child with BPDCN with skin and leukemic involvement. She has been disease‐free for 4 years after allogeneic bone marrow transplantation in first complete remission. In 33 cases of pediatric BPDCN, the over survival was significantly lower in the patients with skin manifestation than those without cutaneous involvement. Accordingly, it is important to determine whether allogeneic hematopoietic stem cell transplantation should be applied to first complete remission in the patients with poor prognosis. Pediatr Blood Cancer 2013;60:E140–E142. © 2013 Wiley Periodicals, Inc.