Central nervous system involvement in anaplastic large cell lymphoma in childhood: Results from a multicentre European and Japanese study | Zendy

Williams Denise | Zendy; Mori Tetsuya | Zendy; Reiter Alfred | Zendy; Woessman Wilhelm | Zendy; Rosolen Angelo | Zendy; Wrobel Grazyna | Zendy; Zsiros Jozsef | Zendy; Uyttebroeck Anne | Zendy; Marky Ildiko | Zendy; Le Deley MarieCécile | Zendy; Brugières Laurence | Zendy

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Central nervous system involvement in anaplastic large cell lymphoma in childhood: Results from a multicentre European and Japanese study

Author(s) -

Williams Denise,

Mori Tetsuya,

Reiter Alfred,

Woessman Wilhelm,

Rosolen Angelo,

Wrobel Grazyna,

Zsiros Jozsef,

Uyttebroeck Anne,

Marky Ildiko,

Le Deley MarieCécile,

Brugières Laurence

Publication year - 2013

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.24591

Subject(s) - medicine , methotrexate , blood cancer , immunophenotyping , chemotherapy , lymphoma , central nervous system , anaplastic lymphoma kinase , vincristine , disease , oncology , cancer , immunology , cyclophosphamide , antigen , pleural effusion , malignant pleural effusion

In an international study of systemic childhood ALCL, 12/463 patients had CNS involvement, three of which had isolated CNS disease. Comparative analysis of CNS positive and negative patients showed no difference in ALK positivity, immunophenotype, presence of B symptoms or other sites of disease. The lymphohistiocytic variant was over represented in the CNS positive group (36% vs. 5%). With multi‐agent chemotherapy, including high dose methotrexate, Ara‐C and intrathecal treatment, the event free and overall survival of the CNS positive group at 5 years were 50% (95%CI, 25–75%) and 74% (45–91%), respectively with a median follow up of 4.1 years. Pediatr Blood Cancer 2013;60:E118–E121. © 2013 Wiley Periodicals, Inc.

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