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Central nervous system involvement in anaplastic large cell lymphoma in childhood: Results from a multicentre European and Japanese study
Author(s) -
Williams Denise,
Mori Tetsuya,
Reiter Alfred,
Woessman Wilhelm,
Rosolen Angelo,
Wrobel Grazyna,
Zsiros Jozsef,
Uyttebroeck Anne,
Marky Ildiko,
Le Deley MarieCécile,
Brugières Laurence
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24591
Subject(s) - medicine , methotrexate , blood cancer , immunophenotyping , chemotherapy , lymphoma , central nervous system , anaplastic lymphoma kinase , vincristine , disease , oncology , cancer , immunology , cyclophosphamide , antigen , pleural effusion , malignant pleural effusion
Abstract In an international study of systemic childhood ALCL, 12/463 patients had CNS involvement, three of which had isolated CNS disease. Comparative analysis of CNS positive and negative patients showed no difference in ALK positivity, immunophenotype, presence of B symptoms or other sites of disease. The lymphohistiocytic variant was over represented in the CNS positive group (36% vs. 5%). With multi‐agent chemotherapy, including high dose methotrexate, Ara‐C and intrathecal treatment, the event free and overall survival of the CNS positive group at 5 years were 50% (95%CI, 25–75%) and 74% (45–91%), respectively with a median follow up of 4.1 years. Pediatr Blood Cancer 2013;60:E118–E121. © 2013 Wiley Periodicals, Inc.