Association between baseline fetal hemoglobin levels and incidence of severe vaso‐occlusive pain episodes in children with sickle cell anemia | Zendy

Bhatnagar Pallav | Zendy; Keefer Jeffrey R. | Zendy; Casella James F. | Zendy; BarronCasella Emily A. | Zendy; Bean Christopher J. | Zendy; Hooper Craig W. | Zendy; Payne Amanda B. | Zendy; Arking Dan E. | Zendy; Debaun Michael R. | Zendy

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Association between baseline fetal hemoglobin levels and incidence of severe vaso‐occlusive pain episodes in children with sickle cell anemia

Author(s) -

Bhatnagar Pallav,

Keefer Jeffrey R.,

Casella James F.,

BarronCasella Emily A.,

Bean Christopher J.,

Hooper Craig W.,

Payne Amanda B.,

Arking Dan E.,

Debaun Michael R.

Publication year - 2013

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.24588

Subject(s) - medicine , fetal hemoglobin , incidence (geometry) , sickle cell anemia , anemia , hemoglobin , disease , acute chest syndrome , pediatrics , vaso occlusive crisis , fetus , pregnancy , genetics , physics , optics , biology

The ameliorating effect of high fetal hemoglobin (HbF) levels on the incidence of pain episodes in sickle cell anemia (SCA) is well‐known; however, in children this relationship is less clearly established. We hypothesized that higher HbF levels in children with SCA are associated with fewer severe pain episodes. A meta‐analysis of data from the Silent Infarct Transfusion Trial (n = 456) and the Cooperative Study of Sickle Cell Disease (n = 764), demonstrated that baseline HbF levels were associated with the incidence of severe pain, commonly defined across studies as an event requiring hospitalization ( P ‐value = 0.02). Pediatr Blood Cancer 2013;60:E125–E127. © 2013 Wiley Periodicals, Inc.

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