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Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: A call for standardization
Author(s) -
Blufpand Hester N.,
Hes Nicole,
Bökenkamp Arend,
van de Wetering Marianne D.,
Kaspers Gertjan J.L.
Publication year - 2014
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24572
Subject(s) - medicine , standardization , childhood cancer , diversity (politics) , function (biology) , renal function , cancer , blood cancer , intensive care medicine , oncology , genetics , biology , political science , law , sociology , anthropology
Abstract Despite changes in survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. To provide cutting‐edge care for children with cancer oncologist must be familiar with their nephrotoxic potential. Careful monitoring of renal function during treatment is therefore indicated. Well‐defined guidelines for this are lacking. We reviewed current DCOG protocols and showed that monitoring of renal function during treatment varies widely between protocols. In some protocols recommended renal function measures are inappropriate given the chemotherapy prescribed. Advices on dose modifications in case of renal dysfunction also vary, even with comparable regimens. These differences are unwanted and call for standardization. Pediatr Blood Cancer 2014;61:337–344. © 2013 Wiley Periodicals, Inc.