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Successful port‐a‐cath salvage using linezolid in children with acute leukemia
Author(s) -
Moreno Rubén B.,
Rives Susana,
Justicia Antonio,
Català Albert,
RuizLlobet Anna,
Toll Teresa,
Estella Jesús
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24520
Subject(s) - linezolid , medicine , teicoplanin , vancomycin , central venous catheter , catheter , surgery , staphylococcus aureus , biology , bacteria , genetics
Central venous catheter (CVC) removal is indicated when persistent catheter‐related bloodstream infection (CRBSI) occurs. This is a retrospective study to analyze the use of linezolid as a salvage therapy for CRBSIs due to coagulase‐negative Staphylococci in children diagnosed with acute leukemia. Seven treatment courses of linezolid were administrated to six patients with port‐type‐CRBSI after non‐effective intravenous vancomycin or teicoplanin treatment. Simultaneous lock and systemic therapy with linezolid avoided the removal of port‐type‐CVC in all cases. Treatment with linezolid was an alternative to catheter removal in these patients. Prospective studies are needed to confirm linezolid effectiveness as a salvage treatment in CRBSI. Pediatr Blood Cancer 2013;60:E103–E105. © 2013 Wiley Periodicals, Inc.