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Relevance of historical therapeutic approaches to the contemporary treatment of pediatric solid tumors
Author(s) -
Green Daniel M.,
Kun Larry E.,
Matthay Katherine K.,
Meadows Anna T.,
Meyer William H.,
Meyers Paul A.,
Spunt Sheri L.,
Robison Leslie L.,
Hudson Melissa M.
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24487
Subject(s) - medicine , modalities , adverse effect , intensive care medicine , remedial education , therapeutic modalities , treatment modality , psychological intervention , blood cancer , cancer , psychiatry , social science , sociology , political science , law
Children with solid tumors, most of which are malignant, have an excellent prognosis when treated on contemporary regimens. These regimens, which incorporate chemotherapeutic agents and treatment modalities used for many decades, have evolved to improve relapse‐free survival and reduce long‐term toxicity. This review discusses the evolution of the treatment regimens employed for management of the most common solid tumors, emphasizing the similarities between contemporary and historical regimens. These similarities allow the use of historical patient cohorts to identify the late effects of successful therapy and to evaluate remedial interventions for these adverse effects. Pediatr Blood Cancer 2013; 60: 1083–1094. © 2013 Wiley Periodicals, Inc.