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Magnesium homeostasis and hypomagnesemia in children with malignancy
Author(s) -
Kaplinsky Chaim,
Alon Uri S.
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24460
Subject(s) - hypomagnesemia , medicine , etiology , malignancy , malnutrition , intensive care medicine , magnesium deficiency (plants) , pathophysiology , pediatrics , cancer , blood cancer , magnesium , materials science , metallurgy
Hypomagnesemia is not uncommon among children with malignancies. It is especially seen in association with certain medications and can be further complicated by the presence of diarrhea and malnutrition. Severe hypomagnesemia may cause disturbances in the neuromuscular and cardiovascular systems. All patients with hypomagnesemia should be supplemented with the mineral, and urgent treatment is indicated when serum magnesium decreases below 1.0 mg/dl, a level under which symptoms may develop. This review addresses the essentials of magnesium physiology, and pathophysiology of hypomagnesemia, its etiologies, clinical manifestations and ways to treat it, with an emphasis on the child with hematologic/oncologic disorders. Pediatr Blood Cancer 2013; 60: 734–740. © 2013 Wiley Periodicals, Inc.