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Lymphoproliferative disorder that resembles heptosplenic lymphoma during maintenance treatment for T‐cell acute lymphoblastic leukemia
Author(s) -
Hu YouJun,
Ahmed Tahmeena,
Zaslav AnnLeslie,
Golightly Marc,
Spitzer Silvia G.,
Raetz Elizabeth,
Chan Edward L.
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24442
Subject(s) - hepatosplenomegaly , medicine , lymphoblastic lymphoma , lymphoma , blood cancer , pleural effusion , chemotherapy , lymphoblastic leukemia , leukemia , pathology , cancer , immunology , t cell , disease , immune system
Abstract A 6‐year‐old male presented with a testicular mass, hepatosplenomegaly, and a pleural effusion while undergoing maintenance chemotherapy for treatment of T‐cell acute lymphoblastic leukemia (T‐ALL). He was subsequently diagnosed with a lymphoproliferative disorder that resembled hepatosplenic lymphoma (HSL). While the extranodal presentation and the protracted yet aggressive clinical course are consistent with HSL, the findings of monosomy 8 and polymorphic cell populations are unique and have not been previously described in this type of lymphoma. Pediatr Blood Cancer 2013; 60: E10–E12. © 2013 Wiley Periodicals, Inc.