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Children's Oncology Group's 2013 blueprint for research: Hodgkin lymphoma
Author(s) -
Kelly Kara M.,
Hodgson David,
Appel Burton,
Chen Lu,
Cole Peter D.,
Horton Terzah,
Keller Frank G.
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24423
Subject(s) - medicine , brentuximab vedotin , oncology , hodgkin lymphoma , gemcitabine , radiation therapy , chemotherapy , lymphoma , clinical trial
In childhood Hodgkin lymphoma, estimated 5 years survival rates exceed 90%. Long‐term survival continues to decline from delayed toxicities. Key findings from recent Children's Oncology Group trials include: (1) Radiotherapy selection may be based on early chemotherapy response assessed by both FDG‐PET and CT imaging, (2) A new prognostic factor score stratifies patients into risk categories; and (3) novel retrieval regimens were identified. A phase I/II trial is investigating Brentuximab vedotin (Bv) with gemcitabine in relapsed patients. A phase 3 trial will modify conventional chemotherapy and radiotherapy approaches through the addition of Bv, while incorporating translational biology to identify molecular targets. Pediatr Blood Cancer 2013; 60: 972–978. © 2012 Wiley Periodicals, Inc.