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Pulmonary hypertension following haematopoietic stem cell transplantation for primary haemophagocytic lymphohistiocytosis
Author(s) -
Zeilhofer Ulrike,
Ashworth Michael,
Amrolia Persis,
Rao Anupama,
Chiesa Robert,
Veys Paul,
Rao Kanchan
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24405
Subject(s) - medicine , hemophagocytic lymphohistiocytosis , pulmonary hypertension , transplantation , hematopoietic stem cell transplantation , stem cell , haematopoiesis , disease , biology , genetics
We report two children who developed severe, fatal pulmonary hypertension (PHT) after mismatched unrelated donor cord blood transplantation using reduced intensity conditioning for HLH. PHT was diagnosed on post mortem lung biopsies with no evidence of HLH, pulmonary veno‐occlusive disease, infection or of idiopathic pulmonary hypertension. PHT may be an association with HLH and physicians treating HLH should be aware of this potential association. Pediatr Blood Cancer 2013; 60: 521–523. © 2012 Wiley Periodicals, Inc.