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Assembly of a cohort of children treated for acute myeloid leukemia at free‐standing children's hospitals in the United States using an administrative database
Author(s) -
Kavcic Marko,
Fisher Brian T.,
Torp Kari,
Li Yimei,
Huang YuanShung,
Seif Alix E.,
Vujkovic Marijana,
Aplenc Richard
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24402
Subject(s) - medicine , cohort , myeloid leukemia , induction chemotherapy , cohort study , medical record , myeloid , pediatrics , clinical epidemiology , epidemiology , chemotherapy , database , computer science
Pediatric Health Information System data were used to establish a multi‐center cohort of 1,686 children treated for newly diagnosed acute myeloid leukemia (AML). The cohort assembly process, which included myeloid leukemia ICD‐9 discharge diagnosis codes and manual review of induction chemotherapy, was validated by chart review at a single institution. The use of ICD‐9 codes alone resulted in a poor positive predictive value (PPV; 31%). Inclusion of the results from the chemotherapy review improved the PPV to 100% without compromising sensitivity (95.7%). This cohort provides a reliable source for future comparative effectiveness and clinical epidemiology studies in pediatric AML. Pediatr Blood Cancer 2013; 60: 508–511. © 2012 Wiley Periodicals, Inc.