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Pharmacokinetic interaction between methotrexate and chloral hydrate
Author(s) -
Dao Kim,
Ivanyuk Anton,
Buclin Thierry,
BeckPopovic Maja,
Diezi Manuel
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24393
Subject(s) - chloral hydrate , methotrexate , medicine , discontinuation , pharmacokinetics , drug interaction , pharmacology , antimetabolite , renal function , clearance , drug , chemotherapy , anesthesia , urology
We report the case of a drug interaction between methotrexate (MTX) and chloral hydrate (CH) observed in a child treated for acute leukemia. Significantly slower MTX clearance and increased MTX exposure occurred on the first three courses of a high‐dose chemotherapy when co‐administered with CH despite normal renal function, adequate hydration, and alkalinization. Mean MTX area under the curve associated with CH administration was 1,134 µmol hours/L, compared to 608 µmol hours/L after discontinuation of CH. This interaction possibly resulted from a competition between anionic CH metabolites and MTX for renal tubular excretion. Pediatr Blood Cancer 2013; 60: 518–520. © 2012 Wiley Periodicals, Inc.