Premium
Demonstration of type II latency in T lymphocytes of Epstein–Barr Virus‐associated hemophagocytic lymphohistiocytosis
Author(s) -
Ito Yoshinori,
Kawamura Yoshiki,
Iwata Seiko,
Kawada Junichi,
Yoshikawa Tetsushi,
Kimura Hiroshi
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24319
Subject(s) - hemophagocytic lymphohistiocytosis , epstein–barr virus , medicine , virology , cd8 , antigen , lytic cycle , immunology , bzlf1 , virus , cytotoxic t cell , epstein–barr virus infection , herpesviridae , disease , biology , viral disease , genetics , pathology , in vitro
Abstract Epstein–Barr virus (EBV) is the most common infectious cause of non‐genetic hemophagocytic lymphohistiocytosis (HLH). To investigate EBV‐infected lymphocytes and immune dysfunction in EBV‐associated HLH, blood samples from a 6‐year‐old boy were longitudinally analyzed using molecular techniques. EBV‐positive lymphocytes were detected as CD5 + , CD8 + , and/or HLA DR + lymphocytes on Day 25 of the disease, mostly disappearing thereafter. CD8 + cells specific for lytic antigen BRLF1 were detected, but cells specific for latent antigens EBNA3 and LMP2 were not. EBV genes EBNA1, LMP1, LMP2, EBER1, BARTs were detected, suggesting a latency type II gene expression pattern in this case. Pediatr Blood Cancer 2013;60:326–328. © 2012 Wiley Periodicals, Inc.