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Detection of respiratory viruses in asymptomatic children undergoing allogeneic hematopoietic cell transplantation
Author(s) -
Srinivasan Ashok,
Flynn Patricia,
Gu Zhengming,
Hartford Christine,
Lovins Richard,
Sunkara Anusha,
Srivastava Deo K.,
Leung Wing,
Hayden Randall T.
Publication year - 2013
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24314
Subject(s) - rhinovirus , asymptomatic , medicine , hematopoietic stem cell transplantation , respiratory system , virus , respiratory tract , transplantation , viral shedding , respiratory tract infections , virology , immunology
Detection of respiratory viruses by molecular methods, in children without respiratory symptoms undergoing hematopoietic cell transplantation (HCT), has not been well described. A prospective study of 33 asymptomatic children detected respiratory viruses in 8 of 33 (24%) patients before HCT. Human rhinovirus (HRV) was detected in five patients, and human adenovirus (hADV) in three patients. Two additional patients shed HRV, and one shed human coronavirus (hCoV), post‐HCT. Two patients had co‐infections. Of the 11 asymptomatic patients where respiratory virus was detected, 3 (27%) later developed an upper respiratory tract infection, from the same virus. Pediatr Blood Cancer 2013; 60: 149–151. © 2012 Wiley Periodicals, Inc.