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Improved outcome in pediatric AML due to augmented supportive care
Author(s) -
Jastaniah Wasil,
Abrar Mohammed Burhan,
Khattab Taha M.
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24195
Subject(s) - medicine , blood cancer , myeloid leukemia , supportive psychotherapy , childhood cancer , pediatrics , retrospective cohort study , protocol (science) , cancer , intensive care medicine , alternative medicine , pathology
Abstract We conducted a retrospective review of patients treated following the MRC acute myeloid leukemia (AML) 10 protocol to determine if supportive care measures sequentially introduced by our institution led to a significant improvement in treatment‐related mortality (TRM) in newly diagnosed pediatric patients with AML. Patients were partitioned based on supportive care measures into era1, from 1996 to 2002 (n = 20), and era2, from 2003 to 2011 (n = 40). The introduced supportive care measures reduced the TRM from 23.4% in era1 to 2.5% in era2 ( P = 0.034). The results demonstrate that supportive care is a significant factor in determining the outcome of childhood AML. Pediatr Blood Cancer 2012; 59: 919–921. © 2012 Wiley Periodicals, Inc.