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A case study of a child with chronic hemolytic anemia due to a Donath–Landsteiner positive, IgM anti‐I autoantibody
Author(s) -
Karafin Matthew S.,
Shirey R. Sue,
Ness Paul M.,
King Karen E.,
Keefer Jeffrey
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24185
Subject(s) - medicine , autoimmune hemolytic anemia , autoantibody , hemolysis , immunology , hemolytic anemia , antibody , anemia , etiology
In children, paroxysmal cold hemoglobinuria (PCH) is generally considered an acute self‐limited autoimmune hemolytic anemia caused by an IgG biphasic auto‐anti‐P antibody identified by the Donath–Landsteiner (D‐L) test. We report a case of a 5‐year‐old female with a chronic hemolytic anemia. The etiology of the hemolysis appears to be an unusual D‐L positive, IgM antibody with specificity for the I antigen. The clinical course is described and a discussion of PCH and the D‐L antibody is presented. We also discuss intravenous immunoglobulin infusions as a therapy for children with this form of severe chronic autoimmune hemolytic anemia. Pediatr Blood Cancer 2012; 59: 953–955. © 2012 Wiley Periodicals, Inc.