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MicroRNA expression and activity in pediatric acute lymphoblastic leukemia (ALL)
Author(s) -
de Oliveira Jaqueline C.,
Brassesco María Sol,
Scrideli Carlos Alberto,
Tone Luiz Gonzaga,
Narendran Aru
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24167
Subject(s) - microrna , medicine , lymphoblastic leukemia , phenotype , leukemia , bioinformatics , oncology , computational biology , cancer research , immunology , gene , genetics , biology
Acute lymphoblastic leukemia (ALL) is the most common type of pediatric neoplasia. Highly heterogeneous, ALL includes several genetic subtypes with varying clinical outcome. Although, some features are well established as prognostic predictors, the details of the molecular mechanisms underlying different phenotypes are only beginning to emerge. Recently, microRNAs (miRNAs) have been shown to influence a range of physiological processes and, consequently, alterations in their expression and functions have been associated with the development of many cancers, including leukemia. This article aims to review the current state of knowledge of the role of miRNAs on the biology of childhood ALL, also including relevant findings from the adult leukemia literature. Pediatr Blood Cancer 2012;59:599–604. © 2012 Wiley Periodicals, Inc.