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An exploratory epidemiological study of Langerhans cell histiocytosis
Author(s) -
Venkatramani Rajkumar,
Rosenberg Shira,
Indramohan Gitanjali,
Jeng Michael,
Jubran Rima
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24136
Subject(s) - medicine , langerhans cell histiocytosis , epidemiology , family history , population , pregnancy , histiocytosis , disease , pediatrics , environmental health , biology , genetics
We explored potential risk factors associated with Langerhans cell histiocytosis (LCH) in a predominantly Hispanic population in Los Angeles. Sixty children with LCH (cases) and, 150 randomly selected patients (controls) were interviewed. There was no statistically significant difference between cases and controls in the following: Family history of thyroid disease, smokers in the family, maternal problems during pregnancy, and pesticide exposure. Cases were more likely to report a family history of cancer (OR 2.5), infection during infancy (OR 2.76), and parental occupational exposure to metal, granites, or wood dust (OR 2.48). Pediatr Blood Cancer 2012; 59: 1324–1326. © 2012 Wiley Periodicals, Inc.