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Gemcitabine and docetaxel (GEMDOX) for the treatment of relapsed and refractory pediatric sarcomas
Author(s) -
Rapkin Louis,
Qayed Muna,
Brill Pam,
Martin Melissa,
Clark Dana,
George Bradley A.,
Olson Thomas A.,
WasilewskiMasker Karen,
Alazraki Adina,
Katzenstein Howard M.
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24101
Subject(s) - medicine , docetaxel , rhabdomyosarcoma , gemcitabine , sarcoma , neutropenia , pediatric cancer , refractory (planetary science) , oncology , cancer , chemotherapy , surgery , pathology , physics , astrobiology
Background Patients with relapsed pediatric sarcomas have a poor outcome and are in need of novel effective therapies. Methods We retrospectively reviewed the records of patients at Children's Healthcare of Atlanta who were treated with gemcitabine (675 mg/m 2 ) intravenously (IV) on Day 1 and Day 8, and docetaxel (75 mg/m 2 ) IV on Day 8, repeated every 3 weeks. Results Nineteen patients with a median age of 11 years were treated from 2006–2010 and received 123 total courses. Two patients (11%), both with rhabdomyosarcoma, demonstrated objectives responses [one complete response (CR) and one partial response (PR)]. Seven other patients (39%) had stable disease (SD). The 1‐year progression‐free survival (PFS) of the entire cohort was 24% ± 10% with a median time to progression of 2 months (range: 0.5–14 months). The 1‐year overall survival (OS) was 43% ± 11%. Grade 3 or 4 toxicities occurred in 14 patients (74%) and 52 courses (42%), and were most commonly hematologic (neutropenia = 37, anemia = 17, and thrombocytopenia = 23 courses). Conclusions The dismal outcomes for patients with relapsed and refractory sarcomas and the lack of effective sarcoma salvage regimens highlight the need for new approaches. This report of the therapeutic activity of gemcitabine and docetaxel (GEMDOX) in rhabdomyosarcoma and other pediatric reports describing activity in osteosarcoma and Ewing sarcoma suggest that this combination should be considered for formal evaluation in a pediatric specific clinical trial. At a minimum, it appears to offer a reasonable, tolerable, palliative option. Pediatr Blood Cancer 2012; 59: 854–858. © 2012 Wiley Periodicals, Inc.