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Hypothalamic obesity syndrome: Rare presentation of CNS+ B‐cell lymphoblastic lymphoma
Author(s) -
Quigg Troy C.,
Haddad Nadine G.,
Buchsbaum Jeffrey C.,
Shih ChieSchin
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24058
Subject(s) - medicine , lymphoblastic lymphoma , lymphoma , toddler , chemotherapy , lymphoblastic leukemia , cancer , oncology , pathology , immunology , leukemia , t cell , immune system , psychology , developmental psychology
Hypothalamic obesity syndrome can affect brain tumor patients following surgical intervention and irradiation. This syndrome is rare at diagnosis in childhood cancer, but has been reported with relapse of acute lymphoblastic leukemia. Here we present a case of hypothalamic obesity syndrome as the primary presentation of a toddler found to have CNS+ B‐cell lymphoblastic lymphoma. Cytogenetic studies on diagnostic cerebrospinal fluid revealed MLL gene rearrangement (11q23). Hyperphagia and obesity dramatically improved following induction and consolidation chemotherapy. We describe a novel presentation of hypothalamic obesity syndrome in CNS B‐cell lymphoblastic lymphoma, responsive to chemotherapy. Pediatr Blood Cancer 2012; 59: 930–933. © 2011 Wiley Periodicals, Inc.