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Leukapheresis in children weighing less than 20 kg
Author(s) -
Sauer Harald,
Roland Haase,
Ulla Lieser,
Ortrud Diwan,
Jürgen Föll
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24048
Subject(s) - medicine , leukapheresis , apheresis , blood cancer , surgery , pediatric cancer , cancer , stem cell , platelet , genetics , cd34 , biology
Abstract Augmentation of standard chemotherapy with peripheral blood stem cells (PBSC) rescue is a standard treatment strategy. However, in pediatric patients weighing less than 20 kg, the collection of PBSC presents a challenge. We report our experience with nine pediatric patients weighing between 4.33 and 19.9 kg and a total of 23 PBSC collection aphereses. None of our patients experienced any major complications. We conclude that PBSC apheresis in children is a safe method. It should be based on a standardized procedure that includes the determination of clinical and laboratory parameters and appropriate monitoring. Pediatr Blood Cancer 2012; 58: 627–629. © 2011 Wiley Periodicals, Inc.