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Isochromosome 17q, MYC amplification and large cell/anaplastic phenotype in a case of medullomyoblastoma with extracranial metastases
Author(s) -
Wright Karen D.,
von der Embse Kendra,
Coleman Jamie,
Patay Zoltan,
Ellison David W.,
Gajjar Amar
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.24002
Subject(s) - isochromosome , medulloblastoma , medicine , pathology , histopathology , phenotype , blood cancer , cancer research , cancer , biology , karyotype , genetics , gene , chromosome
Medullomyoblastoma (MMB) is a rare variant of medulloblastoma, a member of the family of central nervous system (CNS) embryonal tumors. The outcome of standard therapy for CNS embryonal tumors is often unpredictable in the setting of MMB. Here, we present the clinical course and treatment of an almost 4‐year‐old girl with MMB that was characterized by MYC amplification, isochromosome 17q and large cell/anaplastic histopathology. Pediatr Blood Cancer 2012;59:561–564. © 2011 Wiley Periodicals, Inc.