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Neuroendocrine regulation of food intake
Author(s) -
Hagan Scott,
Niswender Kevin D.
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23376
Subject(s) - medicine , food intake , endocrine system , obesity , energy homeostasis , function (biology) , neuroscience , endocrinology , hormone , biology , microbiology and biotechnology
Despite a global obesity epidemic suggesting that human physiology is unable to prevent unhealthy gains in body weight, ample evidence indicates that weight can be tightly regulated. Food intake regulation is complex and in this article we will present a basic endocrine feedback loop model of energy homeostasis. Next, integration of long‐term regulation with short‐term, meal specific regulation and satiety will be discussed. Finally, the role of adiposity signals in modulation of food reward will be highlighted. A basic understanding of the structure–function of these systems will inform the challenges of clinical care for those with disorders of energy balance. Pediatr Blood Cancer 2012; 58: 149–153. © 2011 Wiley Periodicals, Inc.