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The management of menstrual suppression and uterine bleeding: A survey of current practices in the pediatric blood and marrow transplant consortium
Author(s) -
Adegite Enitan A.,
Goyal Rakesh K.,
Murray Pamela J.,
Marshal Mike,
Sucato Gina S.
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23360
Subject(s) - medicine , amenorrhea , pill , gynecology , obstetrics , pregnancy , genetics , pharmacology , biology
Background Current guidelines recommend the use of combined hormonal contraceptive pills for menstrual suppression in pediatric blood and marrow transplant (BMT) recipients but recent research reveals that provider practice varies. This study was designed to describe the current practice for managing menstrual issues, that is, menstrual suppression and uterine bleeding, in pediatric BMT patients and to better understand health care providers' practices in the use of gonadotropin‐releasing hormone agonists (GnRHa). Procedure A cross sectional survey consisting of 53 questions was distributed via email to principal investigators in the Pediatric Blood and Marrow Transplant Consortium (PBMTC). Responses were collected using www.surveymonkey.com . Results Menstrual suppression and uterine bleeding in pediatric BMT patients are primarily managed by pediatric oncologists (97%). The most frequently reported hormonal method used for induction of therapeutic amenorrhea was GnRHa (41%). The top three reasons for choosing a method were greater likelihood of amenorrhea, concerns about side effects, and possible gonadal protection. Continuous combined hormonal contraceptive pills were the most commonly used method for the management of clinically significant uterine bleeding regardless of primary method used for menstrual suppression. Conclusion Despite the 2002 PBMTC guidelines, wide variation in menstrual suppression management practices still exists. Our data show that use of GnRHa is more common than previously reported. Additional research is needed to develop evidence‐based practice guidelines in pediatric BMT patients. Pediatr Blood Cancer 2012;59:553–557. © 2012 Wiley Periodicals, Inc.