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Aggressive peripheral CD70‐positive t‐cell lymphoma associated with severe chronic active EBV infection
Author(s) -
Shaffer Donald R.,
Sheehan Andrea M.,
Yi Zhongzhen,
Rodgers Cheryl C.,
Bollard Catherine M.,
Brenner Malcolm K.,
Rooney Cliona M.,
Heslop Helen E.,
Gottschalk Stephen
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23352
Subject(s) - medicine , lymphoma , immunology , t cell , virus , lymphoproliferative disorders , t cell lymphoma , disease , pathology , immune system
Abstract Severe chronic active Epstein–Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T‐cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T‐cell lymphoma expresses CD70 and is sensitive to killing by CD70‐specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV‐associated T‐cell lymphoma. Pediatr Blood Cancer 2012;59:758–761. © 2011 Wiley Periodicals, Inc.