Aggressive peripheral CD70‐positive t‐cell lymphoma associated with severe chronic active EBV infection | Zendy

Shaffer Donald R. | Zendy; Sheehan Andrea M. | Zendy; Yi Zhongzhen | Zendy; Rodgers Cheryl C. | Zendy; Bollard Catherine M. | Zendy; Brenner Malcolm K. | Zendy; Rooney Cliona M. | Zendy; Heslop Helen E. | Zendy; Gottschalk Stephen | Zendy

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Aggressive peripheral CD70‐positive t‐cell lymphoma associated with severe chronic active EBV infection

Author(s) -

Shaffer Donald R.,

Sheehan Andrea M.,

Yi Zhongzhen,

Rodgers Cheryl C.,

Bollard Catherine M.,

Brenner Malcolm K.,

Rooney Cliona M.,

Heslop Helen E.,

Gottschalk Stephen

Publication year - 2012

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.23352

Subject(s) - medicine , lymphoma , immunology , t cell , virus , lymphoproliferative disorders , t cell lymphoma , disease , pathology , immune system

Severe chronic active Epstein–Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T‐cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T‐cell lymphoma expresses CD70 and is sensitive to killing by CD70‐specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV‐associated T‐cell lymphoma. Pediatr Blood Cancer 2012;59:758–761. © 2011 Wiley Periodicals, Inc.

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