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TP53 codon 72 polymorphisms in favorable histology Wilms tumors
Author(s) -
Cost Nicholas G.,
Mitui Midori,
Khokhar Shama,
Wickiser Jonathan E.,
Baker Linda A.,
Rakheja Dinesh
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23315
Subject(s) - wilms' tumor , genotype , anaplasia , allele , medicine , histology , genetics , gene , single nucleotide polymorphism , wilms tumour , cancer research , pathology , biology
In Wilms tumor (WT), mutations in the gene encoding p53, TP53 , are correlated with anaplasia; however TP53 variants have not been studied in favorable histology (FH) WTs. A single nucleotide polymorphism of TP53 encoding either arginine or proline at codon 72 is suggested to alter in vitro p53 behavior. Therefore, we analyzed tissue from 23 consecutive patients with FHWT to determine allelic and genotypic frequencies of Pro72 and Arg72 variants and correlate this with clinical outcomes. Interestingly, our cohort showed a statistically significant over‐representation of the Arg allele and Arg/Arg genotype. However, the genotypic and allelic frequencies showed no significant correlation with age, stage, or disease recurrence. Pediatr Blood Cancer 2012;59:326–328. © 2011 Wiley Periodicals, Inc.