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Tissue doppler evaluation of systolic and diastolic cardiac functions in long‐term survivors of Hodgkin lymphoma
Author(s) -
Alehan Dursun,
Şahin Murat,
Varan Ali,
Yıldırım Işıl,
Küpeli Serhan,
Büyükpamukçu Münevver
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23281
Subject(s) - medicine , doppler imaging , interventricular septum , diastole , cardiology , ventricle , mitral valve , heart failure , isovolumic relaxation time , doppler echocardiography , blood pressure
Background Monitoring for late adverse events is crucial in long‐term management of childhood cancer survivors. A case–control study to evaluate long‐term cardiovascular status of childhood Hodgkin lymphoma (HL) using tissue Doppler imaging (TDI) was performed. Patients and Methods Patients diagnosed with HL before age of 18 that completed therapy and were in remission and a control group of healthy children were evaluated by echocardiography and TDI. Results Total of 72 HL survivors were included in the study. Median age at diagnosis, remission time, and age at time of echocardiography were 7 (2–16), 9 (2–20), and 17.5 (7–27) years, respectively. TDI revealed decreased S′ velocity, reflecting systolic dysfunction in HL survivors, at medial and lateral mitral annuli and at middle segment of interventricular septum (IVS; P < 0.01) for all. Moreover, TDI showed decreased peak E′ velocity at medial mitral annulus [12.4 cm/s (5.5–16.3) vs. 13.3 cm/s (10.2–18.9), P = 0.03] and at middle segment of IVS [10 cm/s (5.3–16.3) vs. 11.6 cm/s (6.7–16.7), P < 0.01] and prolongation of isovolemic relaxation time at medial and lateral annuli of the mitral valve ( P < 0.01) and at middle segment of IVS ( P = 0.03) suggesting diastolic dysfunction in HL survivors. Conclusion Cardiac dysfunction after childhood cancer therapy may develop after many years. Since systolic and diastolic dysfunction can be seen in these patients periodic echocardiographic screening of both systolic and diastolic function in the survivors of HL might be useful in the follow‐up of these patients. Pediatr Blood Cancer 2012; 58: 250–255. © 2011 Wiley Periodicals, Inc.