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A sequential treatment algorithm for infants with stage 4s neuroblastoma and massive hepatomegaly
Author(s) -
Weintraub Michael,
Waldman Elisha,
Koplewitz Benjamin,
Bloom Allan I.,
Gross Eitan,
Freeman Arnold I.,
RevelVilk Shoshana
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23186
Subject(s) - medicine , neuroblastoma , blood cancer , chemotherapy , stage (stratigraphy) , disease , progressive disease , treatment modality , surgery , pediatrics , cancer , paleontology , genetics , biology , cell culture
Infants with 4s neuroblastoma (NB) and massive hepatomegaly have a guarded prognosis and mortality approaches 30%. We report on eight patients with 4s NB and massive hepatomegaly treated with multiple modalities. One patient had spontaneous tumor regression. Three patients had progressive disease and responded to chemotherapy. Four patients progressed despite intravenous chemotherapy, of whom two died, and two were salvaged with hepatic intra‐arterial chemoembolization. Treatment of infants with stage 4s NB with massive hepatomegaly should be individualized based on disease course. A sequential approach with observation, intravenous chemotherapy, and intra‐arterial chemoembolization, may improve the outcome of these infants. Pediatr Blood Cancer 2012; 59: 182–184. © 2011 Wiley Periodicals, Inc.